Risk Assessment of the Fungicide Talius with the Active Substances Proquinazid

Talius is a new fungicide containing the active substance proquinazid. against cereal powdery mildew (Blumeria graminis) in cereals and grass seed. The risk assessment was finalized at meeting Mai 29, 2012, by VKM’s Scientific Panel on plant protection products (VKM). VKM particular asked Norwegian Food Safety Authority to look following: 
 human health for operators related properties of product. o effects seen studies dog if these warrant classification chronic toxicity. oncogenic liver thyroid. establishment reference values (ADI, AOEL ARfD). Dermal absorption. labelling substances • fate behaviour environment ecotoxical risks with regard proquinazid.
 conclusion as follows: Health:
 concluded that less serious effect (dose-related ocular discharge increase) dogs both 90 days study 1 year-study. opinion cholangiocarcinomas relevant cancer concerned about effects. proposes an NOAEL 1.2 mg/kg bw/day proquinazid based 2 year rats.
 support:
 proposed ADI value 0.01 bw/day. 0.02 bw/day.
 ARfD 0.2 from Authority.
 supports calculations dermal absorption under directions use (2.6 times higher dilution).
 Environment:
 Proquinazid can be persistent prevailing conditions Norway considers results Finnish PEC calculator expects repeated annual applications may cause accumulation soil up equilibrium level conditions.The potential groundwater contamination leaching its metabolites are low. There minimal toxic terrestrial organisms, sediment dwelling aquatic plants, algae application regime. For fish invertebrates calculated provided 3 m buffer zone used.